By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual demise toll of two million, coupled with emerging drug resistance, highlights the necessity for the improvement of recent medications, higher diagnostics, and a tuberculosis (TB) vaccine. Addressing those key matters, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and instructing within the box of TB. It comprises a hundred colour pictures and illustrations that convey readability to the data provided. The atlas takes the bizarre strategy of masking a number of species histopathology, arguably the 1st and really probably the one source to take action. It presents an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal versions. The editors have compiled info that is helping TB scientists to differentiate among the gains of all significant animal types on hand and to take advantage of them with their strengths and barriers in brain. The booklet offers counsel for choosing the simplest animal model(s) to respond to particular questions and to check the efficacy of drug applicants.
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Additional resources for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
In all other models described in this atlas, one can usually differentiate two phases following infection with MTB: an early “acute” phase where total bacterial numbers increase exponentially, followed by a “chronic” phase where bacterial numbers remain roughly constant as a result of acquired immunity. , in the rabbit—Chapter 7—or in the rat—Chapter 9). Whether this mimics immunological processes occurring in human latency remains to be determined. Spontaneous reactivation leading to secondary TB has not been observed in any of the nonprimate species.
Nat Rev Microbiol, 7, 845–855. J. 2008. Experimental tuberculosis: The role of comparative pathology in the discovery of improved tuberculosis treatment strategies. Tuberculosis (Edinb), 88 Suppl 1, S35–47. , 3rd. 2005. Tuberculosis—Metabolism and respiration in the absence of growth. Nat Rev Microbiol, 3, 70–80. M. 2004. A nested case-control study on treatment-related risk factors for early relapse of tuberculosis. Am J Respir Crit Care Med, 170, 1124–1130. , Jr. 2006. Pathogenesis of human pulmonary tuberculosis: Insights from the rabbit model, 1st ed.
1b,c,d) show well-defined nodules at the surface of the lung, with most rabbit lesions displaying a caseous necrotic center not visible in the rat and guinea pig. 1a). The drastic differences which can be visualized in this simple macroscopic view of infected lung tissues from the various species reflect the detailed histopathological findings presented in subsequent chapters. 1 (opposite page)â•… Macroscopic appearance of TB-infected lungs from mouse (a), rat (b), guinea pig (c), rabbit (d), nonhuman primate [NHP] (e), and human (f) origin.