Download Actin-based Motility: Cellular, Molecular and Physical by J. Victor Small, Klemens Rottner (auth.), Marie-France PDF

By J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)

This ebook provides the mobile, molecular and actual elements of strength and stream through the self-assembly of actin, essentially the most considerable proteins present in cells, into cytoskeletal filaments. « Actin-based motile tactics » are accountable for a wide number of motile actions reminiscent of chemotactic locomotion, embryonic and metastatic telephone migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic approaches together with, axis patterning in early embryos, axonal development in mind improvement, and the immune reaction and synaptic plasticity procedures on the starting place of studying and reminiscence. The booklet describes how the lately undertaken multidisciplinary and multiscale methods have explored the molecular and actual mechanisms on the foundation of strength and circulate produced via actin self-assembly. the selected subject matters exhibit how advances were made within the box of mobile motility as a result of the growth in dwell mobilephone imaging, gentle microscopy, more suitable answer within the constitution of enormous protein assemblies, the biochemical research and mathematical modeling of actin meeting dynamics and the advance of nanotechnologies permitting us to degree forces within the diversity of pico- to nano-newtons produced by means of actin assemblies.

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S. Hatano, H. S. Mooseker. 1973. The polymerization of actin: its role in the generation of the acrosomal process of certain echinoderm sperm. J Cell Biol. 59:109–26. , and N. Kallenbach. 1979. Polymerization of actin. VI. The polarity of the actin filaments in the acrosomal process and how it might be determined. J Cell Biol. 81:608–23. , C. Sykes, and J. Plastino. 2008. Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP. J Cell Biol. 181:19–25. P. 1984. Cells into organs: the forces that shape the embryo.

Scar/WAVE is localised at the tips of protruding lamellipodia in living cells. FEBS Lett. 492:215–20. Y. Chung, D. Wessels, S. A. R. A. Firtel. 2002. Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium. J Biol Chem. 277: 49877–87. K. 1973. Cell surface movements related to cell locomotion. In Locomotion of Tissue Cells, CIBA Foundation Symposium. Vol. 14. R. W. Fitzsimmons, editors. Elsevier, Amsterdam.

4 36 36 39 43 46 48 50 51 52 S. -F. V. 2010 35 36 S. Suetsugu and T. 1 Introduction The plasma membrane contains various membrane microstructures, ranging from ∼10 nm to several microns, that are supported by the cytoskeleton and/or membrane binding proteins. These fine structures of the plasma membrane include invaginations, such as caveolae, clathrin-coated pits, and others, as well as protrusions, such as filopodia, lamellipodia, and so on. These fine micro-membrane structures have their own specific morphological characteristics, which have been mainly defined by extensive electron micrographic studies.

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