By Zeliha Yazici, Giancarlo C. Folco, Jeffery M. Drazen, Santosh Nigam, Takao Shimizu
This quantity, the court cases of the twelfth foreign convention on Advances in Prostaglandin, Leukotriene and different Bioactive Lipid examine: uncomplicated technology and scientific purposes, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid examine with certain awareness to melanoma, cardiovascular ailments, gastrointestinal ailments and breathing ailments. particular themes coated comprise the position of leukotrienes and lipoxins in irritation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
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Extra resources for Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications
For both nucleic acids, adducts with LT~ could be readily detected using mass spectrometry. The yield of DNA and RNA adduct increased as the quantity of DNA and RNA in the reaction mixture increased from 25-400 ug, In all cases, the total quantity of adduct was higher for the incubation with RNA compared to an equal quantity of DNA, suggesting that the nucleoside bases present in RNA were more reactive than the nucleosides present in DNA. Reaction of Native DNA with LTA.. In order to investigate whether or not DNA packaged within the nucleus of cells could be a substrate for the reaction with LT~, experiments were carried out with RBL-2H3 cells using conditions to maximize the half-life of LT~.
In order to test if the effect ofIL-4 on LTB4 could be observed in the presence of a more physiological stimulus, control and IL-4-treated (72 hours) monocytes were challenged with opsonised zymosan. 24 ng/2x10 6 cells). 17 IL-4-INDUCED LIPID MEDIATORS CLASSSWITCHING 30 A • COImlOL [J IL-4 ..... r--. -4 24 B 72 Incubation time with IL·4 (hrs) Figure 1. Monocytes (2x106 cells/ml) were cultured in the presence or absence of IL-4 for 24, 48, 72 hours, and activated with A23l87 (5 JlM). l5(S)-HETE (panel A) and LTB4 (panel B) were quantitated in supernatants by specific RIAs after RP-HPLC separation.
8. 9. Baker SR, Boot JR, Jamieson WB, Osborne DJ, Sweatman WIF. The comparative in vitro pharmacology of leukotriene D4 and its isomers. Biochem Biophys Res Commun 1981; 103: 1258-64. Norman P, Abram TS,Cuthbert NJ, Gardiner PI. The inhibition of [3H]leukotriene D4 binding to guinea-pig lung membranes . The correlation of binding affinity with activity on the guinea-pig ileum. Eur J Pharmacol 1990; 182: 301-12. Walch L, Nore1 X, Blick M, Gascard J-P, Dahlen S-E, Brink C. Pharmacological evidence for cysteinyl-leukotriene receptor subtypes in human pulmonary artery muscle.