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By A. Barry Kay, Jean Bousquet, Patrick G. Holt, Allen P. Kaplan

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This quantity booklet is an exceptional reference resource on all features of hypersensitive reaction and allergic illnesses. overlaying nearly each allergic situation, from the immunological and molecular foundation of the allergic reaction to destiny developments in allergic ailment prevention, this new foreign editorial crew (A.B.Kay, Jean Bousquet, Pat Holt and Allen Kaplan) have thoroughly revised and up to date the textual content, from either a systematic and scientific standpoint. References will stay additional to the textual content until eventually it is going to press making this the main up to date booklet to be had within the field.

This moment version contains greater than 1,800 pages contained inside ninety eight chapters.

The expense contains a absolutely searchable spouse CD ROM with the entire textual content and over three hundred pictures from the e-book in complete colour.

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Extra resources for Allergy and Allergic Diseases, 2 Volume Set

Sample text

Wide Gunnar Johannsson Development of a RAdioSorbent Test (RAST) for detection of allergen-specific IgE 1967 Reindert Voorhorst Frederick Spieksma Identification of Dermatophagoides mites as major allergen source in house dust 1967 Bernard Halpern Lymphocyte stimulation test in drug allergy 1967 Roger Altounyan Discovery of sodium cromoglycate as anti-asthmatic drug 1981 K. Frank Austen Biological properties of leukotrienes 1983 Bengt I. Samuelson Identification of leukotrienes as slow-reacting substance of anaphylaxis, role in allergic diseases and in this sense is cytostimulating rather than cytolytic (in which there is destruction of the cells with liberation of preformed histamine).

Lichtenstein Abraham G. E. King Identification of major allergen in ragweed 1966 Barry R. Bloom John R. J. Curry Asthmatics more sensitive than normals to the action of histamine on the respiratory tract 1967 Kimishige Ishizaka Teruko Ishizaka Characterization of reagins as IgE immunoglobulins 1967 Hans Bennich Gunnar Johansson Identification of myeloma ND as IgE immunoglobulin 1967 L. Wide Gunnar Johannsson Development of a RAdioSorbent Test (RAST) for detection of allergen-specific IgE 1967 Reindert Voorhorst Frederick Spieksma Identification of Dermatophagoides mites as major allergen source in house dust 1967 Bernard Halpern Lymphocyte stimulation test in drug allergy 1967 Roger Altounyan Discovery of sodium cromoglycate as anti-asthmatic drug 1981 K.

For these reasons, Janeway and Travers (1995) proposed that cytotoxic or cell-stimulatory reaction are subdivided into type IIa (cytotoxic) and type IIb (cell-stimulating) responses (Fig. 27). Type III reactions (Arthus reactions and “immune complex” or toxic complex syndrome) occur when antigen and antibody, reacting in antigen excess, form complexes which, possibly with the aid of complement, are toxic to cells. As shown by Jack Pepys (1914–96) (Fig. 28), this mechanism operates, at least in part, in farmer’s lung (and other forms of extrinsic allergic alveolitis).

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