Download Antibiotics as Anti-Inflammatory and Immunomodulatory Agents by Bruce K. Rubin, Jun Tamaoki PDF

By Bruce K. Rubin, Jun Tamaoki

Although the possibility of immunomodulation has been famous for a few years there was an explosion of knowledge during this box with relevance specifically to the therapy of power airway illnesses. lots of the paintings during this box has been performed by way of jap investigators yet within the final decade there was a physique of labor outdoors of Japan that helps and complements those findings. The booklet covers easy examine like results on micro organism, anti inflammatory and mucoregulatory results, but in addition scientific effects with updated info for using such drugs to probably deal with ailments as diversified as power airway ailments, arthritis, inflammatory bowel disorder, and melanoma.

The quantity is meant for pulmonary physicians, researchers in irritation study, and pharmaceutical businesses attracted to the advance of such brokers. It presents heritage info for the clinician in addition to intensive exploration of leading edge science.

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Birkhäuser Verlag, Basel, 23–7 55 Tak PP, Firestein GS (2001) NFκB: a key role in inflammatory diseases. J Clin Invest 107: 7–11 56 Seymour RA, Heasman PA (1995) Tetracyclines in the management of periodontal diseases: A review. J Clin Periodontol 22: 22–35 57 Stone M, Fortin PR, Pacheco-Tena C, Inman RD (2003) Should tetracycline treatment be used more extensively for rheumatoid arthritis? Meta-analysis demonstrates clinical benefit with reduction in disease activity. J Rheumatol 30: 2112–22 58 Nieman GF, Zerler BR (2001) A role for the anti-inflammatory properties of tetracyclines in the prevention of acute lung injury.

Sulfonamides inhibit phagocyte functions [75], and sulfasalazine, found to be effective in rheumatoid arthritis in the late 1940s, is still widely used for the treatment of early rheumatoid arthritis and for inflammatory bowel disease [76, 77]. While a number of possible mechanisms of action have been proposed for this antiinflammatory agent, it has recently been suggested to act via inhibition of NF-κB [78]. Pro-apoptotic effects and resolution of inflammation In addition to the modulatory effects of antibiotics on the processes leading to the development of the inflammatory response, there is also evidence for their ability to facilitate the resolution of inflammation through stimulation of apoptosis.

J Invest Dermatol 70: 51–5 25 Nelson S, Summer WR, Terry PB, Warr GA, Jakab GJ (1987) Erythromycin-induced suppression of pulmonary antibacterial defenses: a potential mechanism of superinfection in the lung. Am Rev Respir Dis 136: 1207–12 26 Labro M-T (2000) Interference of antibacterial agents with phagocytic functions: Immunomodulation or “immuno-fairy tales”? Clin Microbiol Rev 13: 615–50 27 Van Rensburg CEJ, Gatner EMS, Inkamp FMJH, Anderson R (1982) Effects of clozamine alone or combined with dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy.

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