Download Biochemistry of Pulmonary Emphysema by C. Grassi, J. Travis, L. Casali, M. Luisetti, R. Corsico PDF

By C. Grassi, J. Travis, L. Casali, M. Luisetti, R. Corsico

Pulmonary emphysema is a sickness which develops due to a localized imbalance among endogenous proteinase inhibitors and proteinases leaking from neurophils in the course of phagocytosis at inflammatory foci in the lung. This quantity not just reports at a biochemical point what's recognized concerning the normal inhibitors and proteinases fascinated about connective tissue destruction in the lung, but additionally indicates novel methodologies for reestablishing right enzyme-inhibitor stability, together with using synthetic or natural inhibitors for supplementation or gene therapy.

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Isolation and characterization of three large pepsin-resistant domains offibrillin. J. Bioi. 1989; 264: 21381-21385 27. : The protein components of the 12-nanometer microfibrils of elastic and nonelastic tissue. J. Bioi. Chern. 1989;264:4590-4598 28. : Immunohistologic abnormalities of the microfibrillar-fiber system in the Marfan syndrome. N. Engl. J. Med. 1990; 32:152-159 29. : The elastin receptor, a galactoside-binding protein. Science 1988; 239:1539-1541 30. : Elastin binds to a multifunctional 97-Kilodalton peripheral membrane protein.

First, TGF-~ added directly to cultures of fibroblasts or smooth muscle cells strongly stimulates elastin55 (Fig. i <1> 0 ::2: c" 0 u ""0 e :::l Q. 0 TGF~(ng/ml) Fig. 3. Transforming growth factor-beta (TGF~) induces a large increase in SMC elastin production. ). Media were collected after 12-72 hand analyzed for elastin production. Significance was tested by the Student's Hest for independent means on triplicate dishes of cells and duplicate assays. Levels of TGF~ as low as 10-100 pg/ml elicited significant increases in elastin production under these conditions.

1986; 233:925-927 11. : Cathepsin L inactivates a1phal-proteinase inhibitor by cleavage in the reactive site region. J. Bioi. Chern. 1986; 261:14748-14751 12. : A catalytically active high-M, form of human cathepsin B from sputum. Biochem. J. 1988; 254:693-699 13. : The cystatins: a new class of peptidase inhibitors. Trends Biochem. Sci. 1987; 12:193-196 14. : Levels of cathepsin B activity and cystatins in human sputum: relationship to inflammation. Scand. J. Clin. Lab. Invest. 1990; 50:509-516 34 15.

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