By C. Grassi, J. Travis, L. Casali, M. Luisetti, R. Corsico
Pulmonary emphysema is a sickness which develops due to a localized imbalance among endogenous proteinase inhibitors and proteinases leaking from neurophils in the course of phagocytosis at inflammatory foci in the lung. This quantity not just reports at a biochemical point what's recognized concerning the normal inhibitors and proteinases fascinated about connective tissue destruction in the lung, but additionally indicates novel methodologies for reestablishing right enzyme-inhibitor stability, together with using synthetic or natural inhibitors for supplementation or gene therapy.
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Additional resources for Biochemistry of Pulmonary Emphysema
Isolation and characterization of three large pepsin-resistant domains offibrillin. J. Bioi. 1989; 264: 21381-21385 27. : The protein components of the 12-nanometer microfibrils of elastic and nonelastic tissue. J. Bioi. Chern. 1989;264:4590-4598 28. : Immunohistologic abnormalities of the microfibrillar-fiber system in the Marfan syndrome. N. Engl. J. Med. 1990; 32:152-159 29. : The elastin receptor, a galactoside-binding protein. Science 1988; 239:1539-1541 30. : Elastin binds to a multifunctional 97-Kilodalton peripheral membrane protein.
First, TGF-~ added directly to cultures of fibroblasts or smooth muscle cells strongly stimulates elastin55 (Fig. i <1> 0 ::2: c" 0 u ""0 e :::l Q. 0 TGF~(ng/ml) Fig. 3. Transforming growth factor-beta (TGF~) induces a large increase in SMC elastin production. ). Media were collected after 12-72 hand analyzed for elastin production. Significance was tested by the Student's Hest for independent means on triplicate dishes of cells and duplicate assays. Levels of TGF~ as low as 10-100 pg/ml elicited significant increases in elastin production under these conditions.
1986; 233:925-927 11. : Cathepsin L inactivates a1phal-proteinase inhibitor by cleavage in the reactive site region. J. Bioi. Chern. 1986; 261:14748-14751 12. : A catalytically active high-M, form of human cathepsin B from sputum. Biochem. J. 1988; 254:693-699 13. : The cystatins: a new class of peptidase inhibitors. Trends Biochem. Sci. 1987; 12:193-196 14. : Levels of cathepsin B activity and cystatins in human sputum: relationship to inflammation. Scand. J. Clin. Lab. Invest. 1990; 50:509-516 34 15.