Download Chitin and Chitosan Derivatives: Advances in Drug Discovery by Se-Kwon Kim PDF

By Se-Kwon Kim

A usual long-chain polymer, chitin is the most element of the telephone partitions of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and inner shells of cephalopods. even if, marine crustacean shells are the first assets of the chitin spinoff chitosan. Chitin and chitosan are important for numerous organic and biomedical purposes, even supposing they've been restricted by way of terrible solubility long ago. present learn specializes in expanding their solubility and bioactivity via molecular transformations. The ensuing derivatives are receiving a lot realization for fascinating homes, corresponding to biocompatibility, biodegradability, and nontoxicity, that cause them to compatible to be used within the biomedical field.

Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments provides present examine developments within the synthesis of chitin and chitosan derivatives, their organic actions, and their biomedical functions. half I discusses simple information regarding the synthesis and characterization of various derivatives, together with the instruction of chitin nanofibers. half II covers chitin and chitosan differences because the foundation for organic functions. It describes antioxidant, anti inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial actions. half III addresses chemically changed and composite fabrics of chitin and chitosan derivatives for biomedical purposes, akin to tissue engineering, nanomedicine, drug supply, and wound dressing.

A must-have reference for newbies and specialists in biotechnology, normal items, fabrics technological know-how, nutraceuticals, and biomedical engineering, this ebook provides a variety of organic and biomedical functions of chitin and chitosan derivatives for drug discovery and development.

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They can induce the healing process of the damaged tissues and mimic functional and morphological characteristic of the organ tissues. Chitosan hydrogels can be prepared by different methods; in each method chitosan is either physically bound or chemically cross-linked to form hydrogels (Dash et al. 2011). A stable hydrogel must be sufficiently strong to form a semi-permanent junction in molecular network and also be able to exchange water with the polymer network. 7). Although the preparation of hydrogels with the physical association is easy, their application is limited because of weak mechanical strength and uncontrolled dissolution (Dash et al.

2010). Doxorubicin conjugated stearic acid-grafted chitosan oligosaccharide (CSO-SA) were shown to be able to effectively suppress the tumor growth and reduce the toxicity in comparison to the commercial doxorubicin hydrochloride injection (Hu et al. 2009). These results are mainly because of the small size of the micelles and their hydrophilic surface that protect them from the mononuclear phagocyte systems (MPS) (Li and Huang 2008). Because of the passive enhanced permeability and retention (EPR) of the particles, the polymeric micelles accumulate in the tumor tissue (Omelyaneko et al.

9 Chitosan Micelles........................................................................................................ 10 Chitosan in Nasal Vaccines......................................................................................... 14 Chitosan Hydrogels...................................................................................................... 3 Chitosan Derivatives................................................................................................................

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