By Jonathan A. Bernstein, Mark L. Levy
Huge, immense growth in bronchial asthma study has been made some time past 50 years, together with a better knowing of its complicated pathogenesis and new and more beneficial remedies. for that reason, the clinical literature has grown substantial and will be tricky to combine. With contributions from a individual panel of world-renowned authors, scientific bronchial asthma: concept and perform provides a finished examine of either the universal and the tougher difficulties confronted by means of all overall healthiness care group of workers who deal with sufferers with bronchial asthma. The booklet is split into seven sections, beginning wi. Read more...
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Additional info for Clinical Asthma: Theory and Practice
Curr Opin Allergy Clin Immunol 2011;11:58–63. Ogawa Y, Calhoun WJ. The role of leukotrienes in airway inflammation. J Allergy Clin Immunol 2007;118:789–798. Dimeloe S, Nanzer A, Ryanna K, et al. Regulatory T cells, inflammation and the allergic response: The role of glucocorticoids and Vitamin D. J Steroid Biochem Mol Biol 2010;120:86–95. 30. Ryanna K, Stratigou V, Safinia N, et al. Regulatory T cells in bronchial asthma. Allergy 2009;64:335–347. 31. Wills-Karp M, Ewart SL. Time to draw breath: Asthma susceptibility genes are identified.
For all these reasons, IL-5 was considered a key molecular target for the treatment of asthma. With the advent of modern biological agents, it became possible to address the hypothesis that IL-5 is a key molecular target for asthma treatment. A number of humanized, monoclonal anti-IL-5 antibodies have become available, including mepolizumab, reslizuamb, and benralizumab. The treatment of patients with mild/moderate asthma with intravenous mepolizumab did not result in a significant clinical or functional improvement either following acute allergen challenge19 or in day-to-day asthma symptoms following more prolonged therapy,20 despite causing substantial reductions in the numbers of eosinophils in the peripheral blood and induced sputum from the airways.
Diet and asthma: Looking back moving forward. Resp Res 2009;10:49. Devereux G, Seaton A. Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 2005;115(6):1109–1117. Nurmatov U, Devereux G, Sheikh A. Nutrients and foods for the primary prevention of asthma and allergy: Systematic review and meta-analysis. J Allergy Clin Immunol 2011;127:724–733. 46. Nurmatov U, Nwaru BI, Devereux G, et al. Confounding and effect modification in studies of diet and childhood asthma and allergies. Allergy 2012;67:1041–1059.