Download Crush Step 1: The Ultimate USMLE Step 1 Review, 1e by Theodore X. O'Connell PDF

By Theodore X. O'Connell

If you happen to know the entire thoughts in Crush Step 1: the last word USMLE Step 1 Review, you'll want to do far better than pass USMLE Step 1: you need to Crush it! Led by means of Theodore X. O'Connell, MD, the writer of the best-selling USMLE Step 2 Secrets and Brochert's overwhelm Step 2, this concentrated, high-yield evaluate of middle content material and try prep options is the best USMLE Step 1 education available for this high-stakes examination. Written and reviewed by means of scholars, citizens, and specialists, Crush Step 1 is the source you must ranking high!

  • Focus on crucial suggestions and grasp them efficiently with up to date, easy-to-read, high-yield insurance of the entire fabric confirmed at the exam.
  • Ensure your comprehension with USMLE Step 1 perform questions following key sections in addition to rapid-review high-yield boxes.
  • Learn how one can examine for USMLE Step 1 with a extra strategic approach via a different specialize in making a choice on and knowing query stems rather than memorizing buzz words.
  • Spend extra time learning and no more time searching due to a well-written, simply obtainable technique, with lots of necessary lists and tables to focus on high-yield data.
  • Depend at the relevance and accuracy of the content because of oversight by way of authors who scored in the 99th percentile at the USMLE Step 1 examination and assessment forums made out of scholars, citizens, and faculty.

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The nature of the amino acid side chain is critical to how proteins interact with their environment. Acidic, basic, and uncharged polar side chains tend to be found on the exterior of soluble proteins and on the interior of proteins found within membranes. Isoleucine, valine, and leucine are branched-chain amino acids that are increased in maple syrup urine disease. ❍ Alanine is an important substrate for gluconeogenesis. ❍ Methionine is a precursor of homocysteine, a product associated with atherosclerosis.

Lactate dehydrogenase converts pyruvate to lactate, forming 2 ATP molecules per glucose molecule and reoxidizing NADH to NAD+. Anaerobic glycolysis occurs in anoxic tissues, red blood cells, and skeletal muscle during intense exercise. There are nine steps in glycolysis. Three regulated enzymes catalyze irreversible reactions in glycolysis: hexokinase, phosphofructokinase, and pyruvate kinase (PK). The first step in glycolysis Sorbitol, a derivative of glucose, is osmotically active and causes formation of cataracts (lens damage), peripheral neuropathy (Schwann cell), and retinopathy (pericytes); these are associated with DM.

2-7): u= Vmax [S] , Km +[S] where Km is the substrate concentration at which the reaction rate is 12 Vmax , v is the velocity of the reaction, and [S] is the substrate concentration. A higher Km means a lower affinity of the substrate for the enzyme. Vmax 1/v Initial velocity (v) 4 1 3 2 Vmax 2 4 3 2 1/Vmax = Y intercept 1 A Km [S] B –1/Km = X intercept 1/[S] Figure 2-7 Michaelis-Menton enzyme kinetics. A, Substrate concentration [S] versus initial velocity (V) for a reaction with Michaelis-Menton kinetics with a constant enzyme concentration.

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